Chlorocarbonyl aryl dichlorotriazines and dyes derived therefrom



3,055,895 CHLOROCARBONYL ARYL DICHLOROTRIAZINES AND DYES DERIVED THEREFROM Asa W. Joyce, Millersville, Md, and Julian J. Leavitt,

Plainfield, N.J., assignors to American Cyanarnid Company, New York, N.Y., a corporation of Maine No Drawing. Filed Dec, 22, 1958, Ser. No. 781,871 Claims. (Cl. 260-248) This invention relates to new intermediates for dyestuffs and to dyestuffs derived therefrom. More specifi cally it relates to compounds of the formula Ar-OOX N N a a N in which Ar is a carbocyclic monocyclic 6-membered aryl ring Whose remaining carbons carry substituents chosen from hydrogen, alkyl, alkoxy and halogen, and X, Y and Z are each chosen from OH, Cl, and Br. Also it relates to compounds of the formula Ar-O OX N N zi LY N in which Ar is a carbocyclic monocyclic 6-membered aryl radical whose remaining carbons carry substituents chosen from hydrogen, alkyl, alkoxy and halogen; X is chosen from Cl, Br, dialkylamino, N-piperidyl, N-morpholino, and the residue of a dyestuff molecule containing an amino group With a replaceable hydrogen, the said hydrogen being replaced to form the bond between said dyestulf residue and the carbonyl group, and Y and Z are each chosen from Cl, Br, and the residue of a dyestuif molecule with a replaceable hydrogen, the said hydrogen being replaced to form a bond between said dyestulf residue and the triazine nucleus, at least one of X, Y and Z being said dyestulf'residue.

Dyes containing the triazine nucleus have been known in the past in several fields of dyestulf chemistry. They have, in the past, had in common the characteristic of a direct linkage through an amino group between the dyestuif residue and the triazine ring. They have usually been formed by the reaction of cyanuric chloride with a dyestuff containing an amino group which has a replaceable hydrogen. Such a reaction is sometimes difiicult to carry out and does not always go in a clean-cut manner. This is especially true when the triazine dyestutf is constructed with more than one dye residue on the triazine, especially when several dyestuffs are used.

We have found that compounds of the formula Ar-O OX N l .4 Y in which Ar is a residue of the benzene series carrying as additional substituents alkyl, alkoxy or halogen groups, and in which X, Y and Z are hydroxy or halogen, such as chlorine and bromine, are intermediates for the formation of new dyestuffs which are exceptional in the ease with which they form such dyestuffs and in the variety of dyestuffs and shades which they may be obtained therefrom. We have further found that the dyestuifs of the similar formula in which at least one of X, 'Y and Z is the residue of dyestulf linked to the molenitecl States Patent 0 v vantage of our invention is that 3,055,895 Patented Sept. 25, 1962 cule through a replacement of a hydrogen on an amino group are valuable dyestulfs of the vat, azo, direct dye and similar fields. Such dyes could have X, Y and Z represent entirely different dyestulf residues and thus produce composite colors or they can all be the same. Also the intermediate compounds, in which only one or two of X, Y and Z are replaced with a dyestulf residue, are similarly valuable dyestuffs in their own right.

It is an advantage of our invention that these intermediates react more readily with the amino dyestulfs'to link a triazine moiety and a dyestutf nucleus into a common molecule. This is of course most especially true of the replacement of X in the above formula since a carbonyl halide reacts more readily than does a triazine halogen. This difference in reactivity further permits the preparation, in a much more clean-cut fashion and with greater ease, of the types of dyestuifs in which there are several different dyestuffs linked to the same triazine molecule and this is a still further advantage of our invention.

It is a further advantage of our invention that the dyestuffs in which X is a color moiety and Y and Z are halogen are stable enough to permit the use of such dyes in high temperature dyeing procedures, a use not normally possible with dichlorotriazinyl dyes. Another adother dyes can be prepared (eg. those in which X is halogen and either or both of Y and Z are dyestulf residues) which have more reactive halogens than normally can be obtained with chlorotriazinylamino dyestulfs. Our invention thus presents an extraordinary flexibility in the dyestuif properties obtainable.

I. INTERMEDIATES The new intermediates of our inventionare prepared from toluguanamides by oxidation with a permanganate to the corresponding carboxybenzoguanamides. These are then subsequently chlorinated to the acid chloride of the carboxyphenyldichlorotriazine. The known starting materials are easily obtained by beginning with an ortho-, meta-, or a para-, toluic acid chloride and reacting it with dicyandiamide. The resulting.toluyldicyandiamide is then hydrolyzed to the biuret with acid, and ring-closed to the toluguanamide by sodium hydroxide in known man- Toluguanamide Carboxybenzoguanamide The starting toluic acid chloride may have other substituents present, such as alkyl, alkoxy or halogen. Ex-

3 amples of the toluic acids which may be used are rtho-, meta?, and para-toluic acid, 2-methoxy-5-methylbenzoic acid, 2-chloro-5-methylbenzoic acid, 2-methoxy-4-methylbenzoic acid, 2-chloro-4-methylbenzoic acid, and the like.

In the above equation there is shown the conversion of the benzoguanamide to the corresponding dichlorotriazine derivative. However it is clearly equivalent to use the corresponding phosphorous pentabromide or thionyl bromide in order to form the corresponding bromo compounds and these bromo compounds are included within the scope of our invention.

The groups X, Y and Z in the intermediates of our invention need not all be the same although the species in which they are all alike are the more readily obtainable. However, for example, species in which only X has become chloro or bromo while Y and Z remain hydroxyl can be obtained readily by careful treatment with thionyl chloride under conditions (lower temperature and restricted mole usage of SOCl which do not go on to replace the triazine hydroxyls. Similarly the compound in which X, Y and Z are all chloro or bromo can be hydrolyzed step wise to make X alone or X and Y hydroxyl, leaving the others chloro or bromo. This interconversion is illustrated in the following schematic equations:

N N SOClz N N 1120 -y 110* J-OH C1 01 N PCl5 N o 0 OH 00 OH N H2O N N l l l l or -o1 or on The various intermediate steps shown can, of course, also be used as dye intermediates by the reaction with a dye amine followed by further reaction to form the halogen derivatives. Thus these intermediates of our invention are quite versatile in the preparation of various dyestuffs of the carboxyphenyltriazine type shown in later paragraphs in this specification. Although the above equation shows the m-carboxyphenyl derivative, the reactions occur also with the para and ortho-isomers, as well as with compounds having other substituents on the molecule.

II. DYESTUFFS placed by the carboxyphenyltriazine nucleus to form the bond to the dye residue. The carbonyl chloride radical will react first and thus, in those compounds of our invention in which the carboxyl group has been transformed into the carbonyl chloride, a clean reaction can be obtained to form the dyes in which X is an amino dye residue and Y and Z in the above formulas remain either chlorine, bromine or hydroxy. Under somewhat differing conditions additional halogens on the triazine can be further replaced, still stepwise to get a complete replacement as well as partial replacement of the halogens. This will be discussed in detail later in the specification, after a discussion of the various amino dyestuffs which can be used.

At least one of the groups X, Y and Z in the generic formula must be, in the dyestuffs of our invention, a residue of an amino dyestuff linked to the phenyltriazine moiety through the amino group. The amino group on the dye residue may be either a primary or secondary amino group in the original dye molecule. It cannot be a tertiary amino group since there would be no replaceable hydrogen by whose elimination there could be formed a further covalent bond with the phenyltriazine moiety. The dye residues which may thus be linked to the phenyltriazine nucleus in the dyestuffs of our invention will be described below in much detail. In that discussion, extensive reference will be made to The Chemistry of Synthetic Dyes, by K. Venkataraman, Academic Press, New York (1952), and to the American Chemical Society, Monograph No. 127, on the Chemistry of Synthetic Dyes and Pigments, by H. H. Lubs Reinhold, New York (1955). While many of the dyestutf residues which may be used in the dyes of our invention will be described in detail in the specification, in order to provide a complete disclosure these treatises are included expressly by reference in this specification as indicated in the various discussions.

The principal limitations on the dyestuff residues which may be used in forming the dyes of our invention is that these dyestuff residues must contain an amino group capable of forming a further covalent linkage, i.e., an amino group having a replaceable hydrogen. Such a definition includes primary and secondary amino groups and excludes tertiary amino groups. In general, a secondary amine is preferably an alkyl aryl amino compound, since the diaryl amines do not react as well. As described below, all the various classes of dyestuffs can be used, but those members which are useable have this factor in common: no matter what the general class of dyestuff involved, the dyestuff residue must have a primary or secondary amino group which can react with the halogens in the carboxyphenyltriazine nucieus to form the dyestuffs of our invention. In general dyestuffs of similar structure are preferred.

When water-soluble dyestuffs are desired, the dyestuff residue should contain an acidic group in order to achieve the proper water solubility. Of the acidic groups, the sulfonate group is of course by far the preferred one with the carboxylate and sulfonamide groups the ones most likely to be used next.

A. The Dyestufi Residues-A10 Dyes Azo dyes are described in Venkataraman in chapters 11-22, inclusive, pages 409704, and in Lubs, chapter 3, pages 96-181. A great many azo dyestuffs are known to the art which have primary or secondary amino groups in their structure. Such compounds, as described in the above-mentioned pages of Venkataraman and Lubs, are expressly included by reference as useable in the formation of the dyestuffs of our invention.

The azo dyes represent probably the largest class of dyestuffs and the class giving the greatest flexibility in structure and color. There can be used in the dyestuffs of our invention all the variations of azo dyes known, such as the monoazo dyes, the disazo, the trisazo, the

tetrakisazo, the mordant dyes, the stilbene dyes, the py- The azo dye itself may be used for the reaction with razolone and thiazole dyes, and the like, so long as the the calhoXyphehyltriazine derivative- However, in the restrictions are met of a primary or a secondary amino case of azo dyes especially, there are alternative methods :group through which they can be attached to the triazine whewby chlofocahhhhylphehyldichlorotfiazinfi may ring. 5 be first reacted with an amino aromatic compound, to

To illustrate the type of dye used in our invention a be used va Coupling component as a Composimple example is as follows, wherein an azo dye derived Rent n [forming the 320 11101661116- In the reaction, for from Z-amino-5-chloro-4-tol-uenesulfonic acid coupled to eXaIhple, Of one mole of an amillohaphthol With dichlol'o- H-acid (S-amino-1-naphthol-3,6-disulfonic acid) is linked triaZinyLbenY1 chloride followed Y Coupling of a diazo through the arm-no group to the carbonyl group of component into the naphthol, there is obtained the same 1 t dyestutf which would be obtained by first coupling into boxyphenyldlch 0m nazme the .free ammonaphthol and then condensing the azo dye- SOaNa 0H stufi with the triazine compound. Similarly, the halogenated triazine compound may be reacted with one N=N amino group in an aromatic diamine and the other amino group can he diazotized and coupled to form the azo G] Naoas sO3Na derivative. These synthetic methods can be illustrated N N by the following equations. In the first, chlorotoluidine- L sulfonic acid is diazotized and coupled with H-acid to C14 C1 form the azo dye and this is then condensed with m-(di- N chlorotriazinyDhenzoyl chloride to give the dichlorotri- Such a dyestulT is prepared 'by reacting one mole of the azinyl benzoylamido azo dye.

SOHNa S'OaNa 11 NH:

H Acid N=N diazo a 01- Cl- Na03S SOaNa OOO1 H3 CH3 N N OI G1 SOaNa 11 NHOO Cl NaO S SOaNa A 0H3 N N SOaNa OH NBA J NH 011 SOaNa I I N I I I =N N=N O1 NaO S -SOaNa NaOaS -SOaNa 01 Ha CH3 Alternatively, the same dyestuif can be prepared by reacting H-acid with m-(dichlorotriazinyl)benzoyl chloride and coupling the reaction product with chlorotoluidinesulfonic acid (CTS) diazo.

aminoazo dye with the dichlorotriazinylbenzoyl chloride. If three moles of the aminoazo dye are used, all three chlorines are replaced.

NaOaS- OH M NaOzS- SOaNa C o 01 0 SO 3N8 A 0H NH NH OH 01 01 N I N c'rs Diazo NaOgS- SO Na NaO3S- SOzNa cool HOBS

WNAN'O-NEE-CO l k/ OH I A O NE )*NH 0 II N H H I O 0 Obviously, if there are further amino groups in the completed dye molecule, or if the dye molecule is capable of further coupling disazo, trisazo and tetrakisazo dyestuffs can be readily prepared, either before or after the diaminotriazinyl radical is placed upon an amino group in the dyestufi residue.

The preparation of the azo dyes may be carried out under conventional conditions, whether the azo dye is prepared first and then reacted with the halogenated carboxyphenyltriazine to form the dyes of our invention, or whether the triazine compound is reacted with either the diazo component or the coupling component and the azo dye is then subsequently synthesized. The reaction of the azo dye or its fragments with the various halogenated carboxyphenyltriazines may be carried out under various conditions. For example, either aqueous or nonaqueous conditions can be used. The reaction under aqueous conditions is carried out in the presence of an acid-binding agent, such as sodium carbonate or potassium carbonate to take up the hydrogen chloride evolved. In a non-aqueous system, if the azo dye contains sulfonic groups, an amine salt of the azo dye, which will confer solubility in an organic solvent, is conveniently used. Such an amine salt as the di-o-tolylguanidine salt is quite conveniently used in the reaction with the carboxyphenyltriazine derivatives. Where there is no water solubilizing group in the azo dye, a non-aqueous system is preferred.

The azo dye residues of the new triazine dyes which form Our invention are derived from various diazo components and coupling components. Examples of the amines which may be used for the diazo components are:

Aniline o-Nitroaniline m-Nitroaniline p-Nitroaniline 0-, m-, and p-Chloroaniline 2-nitro-4-chloroaniline 2-amino-5-nitroto1uene 4-amino-3-nitrotoluene 2-amino-4-nitrotoluene 2-amino-5-chlorotoluene 2-amino-4-chlorotoluene 2-amino-6-chlorotoluene 2,5-dichloroaniline 3,4-dichloroaniline 3amino-4-chlorotoluene o-Anisidine 3-nitro-4-methoxyaniline 4-nitro-2-methoxyaniline 2-nitro-4-ethoxyaniline Dianisidine 4-amino2,S-diethoxybenzanilide 4-amino-2,S-dimethoxybenzophenone Benzidine (including the monoacetyl derivative) Tolidine 4-ch1oro-2-methoxyaniline 2,4-dimethoxy-S-chloroaniline 4-amino-2-methoxy-5-chlorobenzanilide l-naphthylarnine l-aminoanthraquinone 1-amin0-3-chloroanthraquinone 3-amino-4-meth0Xybenzenesulfonedimetharnide 4-methoxy-3-a-rninophenyl ethyl sulfone 5-benzamido-2,4-xylidine 4-methoxy-4'-aminodiphenylamine 4-aminodiphenylamine 4-chloro-2-aminodiphenyl ether 4,4-dichloro-2-an1ir1odiphenyl ether o-Aminodiphenylamine 5-methyl-4-methoxy-2-amino-2-chloro-4'nitroazobenzene 4'-aminodiphenylamino-4-azotoluene 2-amino-4-sulfodiphenyl ether 2-amino-2'-methyl-4-sulfodiphenyl ether 4-aminoazobenzene 4-aminoazobenzene-4'-sulfonic acid 4-aminoazobenzene-3,4-disulfonic acid Orthanilic acid S-methyl-orthanilic acid Z-amino-S-chloro-4-toluenesulfonic acid 4-chloroaniline-2-sulfonic acid Aniline-2,5-disulfonic acid 4-chloro-5-methyl-2-anilinesulfonic acid 2-amino-4-methoxybenzenesulfonic acid 2,4-dimethylaniline-6-su1fonic acid 2-amino-4-trifluoromethylbenzenesulfonic acid 3,4,-dichloroaniline-6-su1fonic acid 3,S-dichloroaniline-6-sulfonic acid 3-methoxyaniline-6-sulfonic acid 4-methylaniline-6-sulfonic acid Dehydrothiotoluidinesulfonic acid 2-arninonaphthalene-4,8-disulfonic acid 2-aminonaphthalene-6-sulfonic acid 2-aminonaphthalene-6,S-disulfonic acid 1-amin0naphthalene-4,5,6 and 8-sulfonic acid Z-a-minonaphthalene-S,7-disulfonic acid Z-aminonaphthalene-7-sulfonic acid p-Phenylenediamine 3,3'-dich1orobenzidine 3,3-benzidinedisulfonic acid 2,2-dichloro-3, 3 '-dirnethoxy-4,4-diaminodiphenyl S-arninopyridine S-aminoquinoline 4,4'-diamin0stilbene-2,2-disulfonic acid 3,S-diaminodibenzothiophene and its sulfonic acid Examples of the compounds which may be used as the coupling components are:

Aniline o-Toluidine m-Toluidine i0 2,5-dimethylaniline o-Anisidine m-Anisidine 2-methoXy-5-methylaniline 2,5-dimethoxyaniline N-methylaniline N-methyl-o-toluidine Nmethyl-m-toluidine N-ethyl-o-toluidine N-methyl-2-methoxy-S-methylaniline N-ethyl-Z-methoXy-5-methylaniline N-methyl-m-anisidine N-ethyl-manisidine 1amino-8-naphthol-6-sulfonic acid 1-amino-8-naphthol-3,6-disulfonic acid 1-amino-8-naphthol-4,6-disulfonic acid 1-methylamino-8 naphtho1-6-su1fonic acid Z-amino-5-naphthol-7-sulfonic acid Z-methylamino-5-naphthol-7-sulfonic acid 1-amino-8-naphthol-2,4-disulfonic acid 1-amino-8-naphthol-4-sulfonic acid 3-methyl-5-pyrazolone 1-phenyl-3-methyl-5-pyrazolone 1- 4-sulfophenyl) -3-methy1-5-pyrazolone 1- (4-chlorophenyl) -3 -methyl-5 -pyrazolone 1-phenyl-3-carbethoxy-5-pyrazolone Acetoacetanilide 4-sulfoacetoacetanilide Bis-acetoacetbenzidide Bis-acetoacetolidide Acetoacetolidide Beta-hydroxynaphthoic acid Arylides of various hydroxy naphthoic acids such as 3-hydroxy-2-naphthanilide 3-l1ydroxy-Z-naphthoyltoluidide and the like Many other coupling components and diazo components are described in the various chapters of Venkataraman covering the azo dyes, found on pages 409-704 of that treatise. Any combination of these components which produces an azo dye having an amino group capable of reacting with the halogenated carboxyphenyltriazine derivative (i.e., a primary or secondary amino group) is capable of forming the dyestuffs of our invention which contain azo dye residues. A great many such dyes are specifically disclosed in these chapters. As stated above, the amino group may be either a primary or a secondary, but not a tertiary amino group. There must be one hydrogen capable of replacement by the carboxyphenyltriazine radical.

B. Vat Dye Residues The various anthraquinone and other polyquinonoid structures which are known collectively under the generic term of vat dyes, are described in Venkataraman in chapters 27-34, inclusive, pages 803-1058.

Examples of some of the anthraquinonoid compounds which may be used are:

l-amino-anthraquinone 2-aminoanthraquinone Z-methyl-l-aminoanthraquinone 2-amino-3-ch1oroanthraquinone 4-methy1-l-aminoanthraquinone 6-methyl-l-aminoanthraquinone 3-chloro-l-aminoanthraquinone 5-chlor0-l-aminoanthraquinone S-benzamido-l-arninoanthraquinone 4- and S-aminoanthraquinone-l (N)2-benzacridones 4- and S-aminoanthraquinone-l (S)2-thioxanthrones 4-aminoanthrapyrimidine 4-amino-2,3-benzanthraquinone 1,9-pyrazolanthrone Aminodibenzanthrone 4-aminoanthraquinone-1 (N) ,2, l (N) 2-carbazole 1,4-diamino-2-(2,3-anthraquinonethiazolyl) anthraquinone 1,9-thiazoloanthrone l-chloro-Z-aminoanthraquinone Z-amino-3-rnethylsulfonylanthraquinone Z-amino-6-benzarnidoanthraquinone l-arnino-4-(4-arninophenylamino)-anthraquinone- 2,3-disu1fonic acid 1-methylamino-4- (4- nophenylamino) -anthraquinone-2,3'-disulfonic acid 1-amino-4- (4-aminophenylamino) -anthraquinonedisulfonic acid 1-amino-4 (4-aminophenylamino) -anthraquinone- 2,3',5'-trisulfonic acid 1-amino-4- (4' [4"-aminophenylaz0] -anilino -anthraquinone-2,5,2-trisulfonic acid 1-amino-4- (4 [4-aminophenyl] -anilino) -anthraquinone- 2,5,3"-trisulfonic acid l-amino-4- (4'-aminophenylamino) -anthraquinone- 3'-sulfonic acid 1-an1ino-4- 3 -aminophenylamino) -anthraquinone 4-sulfonic acid 1-amino-4- (4'-aminophenylamin0) -anthraquinone-2- sulfonic acid l-amino-4-( 3 -amino-4-methylphenyl amino) -anthr aquinone-Z-sulfonic acid 1=arnino-4-(4-amino-3'-methylpl1enylamino) -anthraquinone-Z-sulfonic acid 1 1-an1ino-4-(3'-amino-4,6-dimethylphenylamino)- anthraquinone-Z-sulfonic acid 1-amino-4- (4-aminophenylamino) -anthraquinone-3'- sulfonic acid diethylarnide In addition to this list there is a class of anthraquinonoid compounds which may be represented by the formula:

Of especial interest along this line are the acid anthraquinone dyes described in chapter 29 of Venkataraman, pages 834-860, wherein a large number of compounds having solubilizing groups are described.

Vat dye residues without solubilizing groups may be selected from any of the amino-substituted vat dyes or vat dye intermediates shown in pages 8034058 of Venkataraman. When vat dyes are desired, at least two vat dye residues must be linked to the carboxyphenyltriazine nucleus.

C. Phthalocyanine Residues The phthalocyanine structure is known to be a highly stable and highly colored chemical structure. Its use in pigments is well known and is described in Venkataraman chapter 38, pages 1118-1142. Various amino substituted phthalocyanines are known including many which are sulfonated or carboxylated or Otherwise substituted by an acid grouping. Such compounds with or without solubilizing groups are readily usable in preparing the dyes of our invention. The amino groups may be directly on the phthalocyanine rings or they may be in a side-chain such as an aminomethyl group. The latter is preferred because of the ease of preparation, since such products can be prepared from the phthalocyanine itself by treatment with methylolphthalimide and sulfuric acid as described in the United States Letters Patent 2,761,868 to Lacey. Sulfonation can occur at the same time under the proper conditions and up to four aminomethyl groups can readily be introduced as Well as up to four sulfonic acid groups. Also phthalocyanine car-boxylic acids can be aminomethylated in the same manner. Similarly, the nuclear substituted phthalocyanines such as those containing one to four chlorines can be sulfonated and/ or aminomethylated. The total number of substituents should not exceed nine in one phthalocyanine molecule. The phthalocyanines are in the form of copper, cobalt, nickel or other metal complexes in which form they are also used in our invention. When phthalocyanines without solubilizing groups are used, the products are pigments only, unless a second dye of another class is also combined with the triazine derivatives.

D. Other Dyestufi Classes The other classes of dyestuffs which are known are generally of less importance than the three classes described above. However, they may have the necessary combination of an acid grouping and a primary or a secondary amino group, and when they do they can be used in the preparation of dyestufis of our invention. Compounds having the necessary prerequisites can be found among the Xanthene, acridine and azine dyestuffs, e.g., described on pages 740-795 of Venkataraman.

A complete line of the dyes of our invention will necessarily include azo structures, vat structures, and phthalocyanines, at least, in order to get the minimum variety needed of colors and properties.

III. PREPARATION OF DYESTUFFS The dyestuffs of our invention are prepared by the ordinary acylation procedures by which carboxylic chlorides are reacted with amines and triazinyl chlorides are reacted with amines. These procedures will vary generally, depending on the amines used and consequently, the procedure modifications used will depend upon What amino dyestulf residue is being introduced into the molecule.

In general, the carbonyl chloride group on the phenyl portion of the molecule will react with an amine first. When only one mole of an amino dyestutf is used this is the chlorine which is replaced and the resulting product is a dichlorotriazinylbenzamide. With the use of larger quantities of dyestuff amine and of more drastic temperatures as described above, the triazine chlorines are readily replaced. Thus, if a second difierent amine is used a mixed dye is obtained. This can be done stepwise, so that dyestuffs having one, two or three amino dyestuff residues can be prepared, the amino dyestufl residues being the same or different.

In the preparation of the dyestuffs of our invention, as an alternative, the carboxyl chloride substituents can be reacted with amines other than dyestulf amines, provided the chlorines on the triazine ring are replaced by at least one amino dyestuif moiety. Such other amines include dialkylamines such as dimethylamine, diethylamine, dipropylarnine and the like, piperidine and morpholine. However, when the triazine chlorines or bromines are then replaced, they must be replaced by amino dyestufi; residues. If the triazine chlorines remain on the molecule, in order 13 to have a dyestufr the carbonyl chloride substituent must have been reacted with an amino dyestufi.

Any of the intermediates described in preceeding portions of this specification can be used to give dyestuffs by replacing the halogens present. Any hydroxyl then remaining can be converted into halogen and used for further replacement by amino dyestuff if such is desired. That is, the use successively of several diiferent dyestuffs permits the obtaining of a wide variety of shades. One may have mixtures of different amino vat dyes, different azo dyes, or diflerent aminophthalocyanines. One can also have mixtures of amino vat dyes, amino azo dyes or of three different kinds of dyestuffs. In general, when one has at least two azo groupings, one applies the compounds like an azo dyestuff. Similarly, if one has at least two amino vat dye structures linked to the phenyltriazine nucleus, one uses the product as a vat dye. If the amino dyestulf substituents in the dyestuffs of our invention have at least two solubilizing groups, the product can be applied as an acid dye. If they have no solubilizing groups, the product may be used as a pigment unless it can be applied as a vat dye. The dyestuffs which have chlorines remaining in the molecule may also be applied by techniques involving the reaction of these chlorines with fibers. The various types of dyestuffs which form our invention and their modes of application can be illustrated by the following table in which X, Y and Z refer to the general formula Ar-O OX starting with p-toluie acid. The corresponding Z-methoxy- S-methyl-benzoyl derivative is obtained by starting with -n1ethoxy-S-methyl-benzoyl chloride.

EXAMPLE 2 EXAMPLE 3 HO OH To a solution of 60 parts of potassium hydroxide in 1100 parts of Water is added 42.7 parts of m-toluyl-biruet prepared as described in Example 2. After stirring and Aminoazo dye 1 Amiioazo dye 1 Acid dye.

Pigment (possibly acid dye if suificiently soluble). Pigment.

Amino vat dye Amino vat dye Vat dye or pigment. do Aminoazo dye Do. Do. do do. Acld dye or vat dye. Aminophthalocyanine do Amino vat dye Vat dye or pigment.

D0 Aminophthaloeyanine Aminoazo dye Pigment. Do. Aminophthalocy Acid dye.

Amino coupling component: Amino diazo component Amino vat dye Azoic dye with diazo developer. Diazo developer with naphthol. Vat dye.

Aminoazo dye Aminoazo dye 1 Chlorine" Acid dye or dye reacting with fiber.

D0. Chlorine do Do. I

Ohlorine Amino vat dye-.. do Dye reacting with fiber.

Do Aminoazo dye 1 Aminoazo dye Acld dye or dye reacting with fiber.

1 Sulfonated.

EXAMPLE 1 A mixture of 67.5 parts of dicyandiamide, 560 parts of acetone and 5 parts of water is cooled to 0 C 64 parts of potassium hydroxide is added and, while stirring at 0 to 5 C., there is added dropwise, gradually a solution of meta-toluyl chloride prepared by chlorination of 49.7 parts of m-toluic acid in 80 parts of acetone. After stirring for 2 hours, the temperature is allowed to rise gradually to 10 C. The mixture is then drowned in 2500 parts of Water, containing parts sulfuric acid. The solid precipitate is removed by filtration and Washed acid-free.

The corresponding p-toluyl derivative is obtained by After stirring and incr EXAMPLE 4 COOH HOK JOH N To a solution of 21.8 parts of potassium hydroxide and 1500 parts of water at 50 C. is added 35.7 parts of m-toluguanamide (2-m-tolyl 4,6 dihydroxy-s-triazine).

easing the temperature to 60 C complete solution is obtained. To the solution isthen added 55.5 parts of potassium permanganate in small proportions over a period of many hours, a fresh portion of permanganate being added only when a test spot on paper shows no permanganate color. The slurry is then filtered to remove manganese dioxide. The filter cake is washed with hot water and any color in the filtrate is discharged by the addition of a small amount of sodium bisulfite. The clear colorless filtrate is then acidified at 30 to 40 C. with about 60 parts of concentrated hydrochloric acid and the white crystalline precipitate is removed by filtration, washed with water and dried.

The following products are prepared using a procedure similar to that described above but using an appropriately substituted methyl-benzoguanamide:

o-Car-boxybenzoguanamide m-Carboxybenzoguanamide p-Carboxybenzoguanamide 2-methoxy-5-carboxybenzoguanamide EXAMPLE 5 N N (ll-k J-Cl N To 55 parts of chlorobenzene is added 9.4 parts of meta-carboxybenzoguanamide. With stirring is then added 25 parts of phosphorus pentachloride and 0.2 part of triethylamine sulfur trioxide complex. The mixture is heated with stirring at the reflux temperature until the reaction is substantially complete. After several hours at the reflux temperature, about 0.5 part of phosphorus oxychloride triethylamine complex is added. A small amount of solid material is removed by filtration. The chloro-benzene is removed from the filtrate by vacuum distillation, giving the crude product which is purified by recrystallization from methyl cyclohexane.

The following acid chlorides of 2-carboxyphenyl-4,6- dichlorotriazines are prepared using a similar procedure:

o-Carboxy p-Carboxy Z-methoxy-S-carboxy By using equivalent amounts of phosphorous pentabromide and phosphorus oxybromide, the corresponding bromo derivatives are obtained.

EXAMPLE 6 To 82 parts of nitrobenzene is added 2.9 parts of the acid chloride of 2-(m-carboxyphenyl)-4,6-dichloro-striazine and 6.7 parts of l-aminoanthraquinone. The mixture is heated with stirring. A reaction starts at about C. with evolution of hydrochloric acid. The heating is continued and at about C., a second reaction starts and the slurry thickens. An additional 55 parts of nitrobenzene is added. The heating with stirring is continued at C. to C. until the reaction is substantially complete. The mixture is cooled. Two parts of sodium carbonate is added and the mixture is warmed to 60 C. The solid product is then removed by filtration, washed and dried. The product dyes cotton a yellow shade from a claret vat.

EXAMPLE 7 goo-NIL i? AN 9 EXAMPLE 8 -O (JO-NH- -NHCOOnHr N N 0 NHL )NH 0 H I N H I l O NH NH O JO-CaH5 JEOCI:H5

The procedure of Example 6 is followed, using an equivalent quantity of 1-amino-4-benzamido-anthraquinone in place of the l-aminoanthraquinone, to give the above product which dyes cotton a red of excellent fastness.

17 EXAMPLE 9 o OONH NE NH 0 II N i ll The procedure of Example 6 is followed using an equivalent amount of the acid chlorine of 2-(p-carboxyphenyl)-4,6-dichloro-s-triazine in place of the acid chloride of 2-(m-carboxyphenyl)-4,6-dichloro-s-triazine, to give the above yellow dyestulf.

EXAMPLE O OONH N N O NH-L NH O u N u i ll O 1 O1 0 The procedure of Example 6 is followed, using the acid chloride of the paracarboxy compound in place of the m-carboxy compound, and using 1-amino-4-chloro-anthraquinone in place of the l-aminoanthraquinone, to give the above product which dyes cotton a reddish shade of yellow.

EXAMPLE 11 O O-NH NH-COCgHg The procedure of Example 6 is followed, using the acid chloride of the p-carboxy compound in place of the m-carboxy compound, and using 1-amino-4-benzamidoanthraquinone in place of l-aminoanthraquinone. The product dyes cotton a red color.

EXAMPLE 12 ALL (where A is an waminoanthraquinone residue linked through the amino nitrogen.)

The procedure of Example 6 is followed, using the acid chloride of 2-(2-methoxy-S-carboxyphenyl)-4,6-dichloros-triazine in place of the acid chloride of Z-(m-carboxyphenyl) -4,6-dichloro-s-triazine, and using the various aminoanthraquinones shown below.

Amine: Dye color I-aminOanthraquinone Yellow. 1-amino-4 benzamidoanthraquinone Red.

1 amino-4-( 3 methylsulfonylbenzamido)- To 2.9 parts of the acid chloride of Z-(m-carboxyphenyl)-4,6-dichloro-s-triazine in 70 parts of nitrohenzene is added gradually 0.75 part of diethylamine in 10 parts nitrobenzene. Then one part of triethylamine is added and the mixture is stirred and warmed gradually to 50 C. To the mixture at this temperature is then added 4.4 parts of l-aminoanthraquinone. The whole is then heated gradually with stirring to a temperature of 135 C. and is then held at this temperature until the reaction is substantially complete. Two parts of triethylamine is then added and the solid is removed by filtration. The product dyes cotton yellow.

Similar products are obtained when equivalent amounts of dipropylarnine, dioctylamine, morpholine, or piperidine are substituted for the diethylamine.

EXAMPLE 14;

A mixture of 3.8 parts of 2-amino-7-chloro-3,4-phthaloylacridone in 110 parts of nitrohenzene is stirred at 185-190 C. until solution is achieved. It is then cooled to 40 C. and 2.9 parts of the acid chloride of 2-(rncarboxyphenyl)-4,6-dichloro-s-triazine is added. The mixture is heated gradually to 100 C. and is then stirred at 100-110 C. until the reaction is substantially complete.

Then 4.5 parts of l-arninoanthraquinone and 40 parts nitrohenzene are added and the whole is heated at 145- 150 C. with stirring until the further reaction is substantially complete. The solid product is removed by filtration at 60 C., washed and dried. The product dyes cotton a blue grey color.

$0113 CHs) 6 To 4.7 parts of 5,8-dibenzamido-l-aminoanthraquinone slurried in parts of nitrohenzene is added 2.9 parts of the acid chloride of Z-(m-carboxyphenyl) -4,6-dichloros-triazine. The mixture is very gradually heated to C. Then 5.1 parts of l-amino-4-methoxyanthraquinone and 2 parts of dimethyl cyanamide are added and the mixture is stirred at -130 C. until the reaction is substantially complete. The solid is removed by filtration, washed and dried. It dyes cotton a red color.

EXAMPLE 16 and To a slurry of 2.25 parts of l-aminoanthraquinone and 110 parts of nitrohenzene at 30 C. is added 2.9 parts of the acid chloride of 2-(p-carboxyphenyl)-4,5-dichloro-striazine. The mixture is heated to 4748 C. gradually and it is then stirred at 48-55 C. until the reaction is substantially complete. The solid dichlorotriazine compound is removed by filtration, washed and dried.

A mixture of 3.3 parts of the yellow dichlorotriazine compound and 4.8 parts of 1-amino-4-benzamidoanthraquinone in 110 parts of nitrohenzene is heated gradually to C. with stirring. The mixture is stirred at 140 C. to C. until the reaction is substantially complete. The solid product is removed by filtration, washed and dried, giving 6.6 parts of product which dyes cotton a brick red shade from a red-violet vat.

EXAMPL 17 and A slurry of 3.8 parts of 2-amino-7-chloro-3,4-phtha1oyl acridone in 110 parts of nitrobenzene is heated at 195- 200 C. until the acridone has dissolved. It is then cooled to 40 C. and 2 parts of the acid chloride of Z-(p-carboxyphenyl)-4,6-dichloro-s-triazine dye can be isolated by cooling, filtering and washing. It dyes cotton a bluegray shade from a violet vat.

To the mixture containing the dichlorotriazine dye is added 5.1 parts of 1-amino-3-chloro-anthraquinone and 2.2 parts of chlorobenzene. The mixture is heated at 170-175 C. until the reaction is substantially complete. It is then cooled. At 40 C. the solid product is removed by filtration, washed and dried. The product dyes cotton a green color from a violet brown vat.

EXAMPLE 18 I .cottonan olive green shade.

0 to the filtrate is added 6.8 parts product dyes cotton a red color.

To parts of molten phenol is added 5.1 parts of 2-(1,4-diamino-2-anthraquinonyl)-anthra-(2,3-d) thiazole-5,10-dione. The mixture is heated to the boiling point to remove Water and is then cooled to 75 C., at which temperature 2.9 parts of the acid chloride of 2- (4-carboxyphenyl)-4,6-dichloro-s-triazine is added. The mixture is slowly warmed to 100-105 C. and is then stirred at this temperature until the reaction is substantially complete. To it is then added 4.5 parts of 1- aminoanthraquinone and the mixture is then stirred at C. until the second reaction is substantially complete. The solid is removed by filtration and slurried in dilute sodium carbonate solution at about 80 C. Y The solid is removed by filtration, Washed and dried. The product dyes cotton green shades from a brown-violet vat.

EXAMPLE 20 ll I'm l'mll A mixture of 3.2 parts of the acid chloride of 2-(2- methoxy-S-carboxyphenyl)-4,6-dichlorotriazine and 1.75 parts of morpholine in 65 parts of o-dichlorobenzene is warmed to 65-75 C. until the reaction is substantially complete. A small residue is removed by filtration and of 1-amino-4-benzamidoanthraquinone and an additional v55 parts of o-dichlorobenzene. The mixture is heated with stirring at 130135 C. until the reaction is substantially complete. The solid product is removed by filtration, Washed and dried. The

EXAMPLE 21 GHzCHaOH CON CHzCHzOH OHaO N T O NE NH NF n n O O The solid material is removed by filtration, washed I well and dried. The product dyes cotton a reddish yellow shade.

EXAMPLE 22 NH: O

01 HOaS H N 1 11 1 O--NH NH 0 SO Na A solution of 5.4 parts of disodium salt of 1-amino-4- (4-aminoanilino)-anthraquinone-2,2 disulfonic acid in 125 parts of water at 10 C. is added gradually with good agitation to a solution of 2.9 parts of 2-(m-chlorocarbonylphenyl)-4,6-dichloro-s-triazine in 35 parts of acetone at 10 C. 8.4 parts of a 10% NaHCO solution is then added to the mixture and the mass stirred at 510 C. until the reaction is substantially complete, while adding two parts more NaHCO to maintain faint alkalinity. T o the dark blue slurry is then added 25 parts sodium chloride and after an hour, the solid is filtered at room temperature and the cake washed with a solution of 25 parts NaCl, parts NaH PO -H O and 6 parts Na HPO in 125 parts water. The wet cake is then dried at -45 C. The product dissolves in water with a greenish-blue color and in concentrated H 50 with a blue color. It dyes cotton a blue shade of excellent wash fastness when applied by the procedure of Example 24.

EXAMPLE 23 or )-N N NaO;

sogNa SOsNfl I A 6.4 part portion of the trisodium salt of the aminoresulting solution is poured gradually with stirring into a solution of 2.9 parts of 2-(m-chlorocarbonylphenyl)-4,6- dichloro-s-triazine dissolved in 35 parts acetone and cooled to 5 C. 10 parts of a 10% NaHCO solution is added and the mixture stirred while it is gradually warming to 10 C. Then 10 parts more 10% NaHCO is added and the stirring is continued several hours at 20 C. The mixture is then warmed to 25 C. and 25 parts sodium sulfate is added. The mixture is stirred at room temperature to get homogeneity. The slurry is then filtered and the filter cake is washed with 20% Na SO solution. The wet cake is dried at 20 to 45 C. The product dissolves in concentrated sulfuric acid with a bluish red color and in water with a red color. It dyes cotton bright bluish-red shades when applied by procedure of Example 24.

EXAMPLE 24 A dye solution is prepared by dissolving 2 grams of the dye of Example 23 in 100 grams of water containing 0.3 gram of surface active agent (polyoxyethylene esters of mixed fatty and resin acids). A piece of cotton fabric is padded in this solution at about l60-l75 F. and is then removed and passed through rollers adjusted to allow an pick up. The cloth is then dried.

The piece of dried fabric is then padded in m1. of a chemical pad bath containing 30 grams of sodium chlo ride and 5 ml. of 30 B. sodium hydroxide solution. It is removed and passed through rollers adjusted to allow about a 50% pick up. The temperature of this pad bath should be at about room temperature, about 20 C. The fabric is then steamed for a short time at 335 F.

'Non-bonded dye is then removed from the fabric by soaping at the boil. This involves heating at the boiling point in a solution containing about 2 grams per liter of an oleate soap. The cotton fabric is dyed a bluish-red color of excellent wash fastness.

EXAMPLE 25 O O-NH 01* J-NH-CHz-POY EXAMPLE 26 Fey-N114 J-NH-Pcy N The procedure of Example 16 is followed using an equivalent amount of monoaminophthalocyanine for the 25 benzoylamino l-aminoanthraquinone. The product is a green blue pigment.

EXAMPLE 27 OO-NH- Ha l? GEL )431 Pcyzphthalocyanine The procedure of the first paragraph of Example 16 is followed using triaminomethylphthalocyanine in /3 the equivalent amount to the usage of aminoanthraquinone. The product is a dyed cotton blue by the procedure of Example 24.

EXAMPLE 28 One equivalent weight of the product of Example 5 is dissolved in approximately 6 times its weight of mono chlorobenzene. To this mixture is added one equivalent weight of water and the mixture is stirred at 6070 C. until hydrolysis of the carboxy chlorine is complete. Slightly over two equivalent Weights of l-aminoanthraquinone is then added and the mixture is heated gradually to 140 C. It is stirred at 140150 C. until the reaction is complete. The mixture is then cooled and an excess of a one equivalent of thionyl chlorine is then added. The mixture is then heated at IOU-120 C. until the reaction is substantially complete. The product separates from the reaction mixture when it is cold. It is isolated by filtration and washing.

One equivalent weight of the product of Example 5 is added to approximately 6 times its weight of monochloro benzene. Approximately two equivalent weights of water is then added and the mixture is heated slowly to approximately 140 C. until hydrolysis of two of the chlorines is substantially complete. The chlorobenzene is thenremoved by vacuum distillation. The product is then used in the procedure of the second paragraph of Example 16 using this product in equivalent quantity in place of the dichloro product used there and half the quantity of l-amino-4-benzamido anthraquinone. The product of this reaction is then used in the procedure of Example 5 using only /3 the equivalent quantity of phosphorus pentachloride. The dichloro compound is recovered by filtration from the chlorobenzene solution and is washed with alcohol and then dried.

EXAMPLE 30 Wkly 01 A one-mol quantity of the product of Example 5 is heated to 50-60 C. in 50 parts of chlorobenzene to which a one-mol quantity of Water and a three mole quantity of pyridine has been added. On cooling, the carboxyphenyl dichlorotriazine separates.

This product, when used in the procedure of Example 6 with half the quantity of aminothraquinone, gives 2 (m-carboxyphenyl)-4 (1 anthraquinonylamino)-6- chloro-s-triazine, which on retreatment by the process of Example 5 gives the corresponding Z-(m-chlorocarbonylphenyl)triazine compound.

EXAMPLE 31 EXAMPLE 29 The procedures of the preceding examples are followed using the proper equivalent quantities of the appropriate C0-C1 carboxyphenyl tn'azine intermediate and the appropriate amino dyestufi to give the dyestuffs shown in the following table in which Ar, X, Y and Z refer to the general 0 formula N N Ar-O 0X 0- L NH N 01 N N mmoouu- L l ArG0-- X Y Z -l| IH (|)H Same as X Same as X.

NflOaS- SOaNQ NH (HI N=N 01.

NaO S- SOaNa -NH OH =N-O 01 0 Naols SOQNB Ar-O X Y 2 NH I I! 0:0 0 0 c1 01.

' 8 II'IH SOsNa OH N= oo-mnQ 00 NH 01 01.

SOaNa We claim: 4. The compound of the formula II. Compounds of the formula N/Y C OX X1 1.

in which X is selected from the group consisting of chlorine and bromine, all the halogen constituents in any one compound being identical.

2. The compound of the formula 3. The compound of the formula 5. The compound of the formula References Cited in the file of this patent UNITED STATES PATENTS OTHER REFERENCES Nencki: Ber. d. Deut. Chem. Ges., vol. 9, pages 232- UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent Noa 3,,O55 895 September 25 1962 Asa W0 Joyce et a1 It is hereby certified that error appears in the above numbered patent requiring correction and that the said Letters Patent should read as corrected below.

Column 16, lines 16 to 37 the upper right-=hand portion of the formula should appear as shown below instead of as in the patent:

column 17, line 31 for "chlorine" read rm chloride column 23 line 22 for ".Q -aminoanthraquinone" read l aminoanthraquin one Signed and sealed this 14th day of May 1963.

(SEAL) Attest: ERNEST W. SWIDER DAVID L. LADD Attesting Officer Commissioner of Patents 

1. COMPOUNDS OF THE FORMULA 